BTNL2 gene variant and sarcoidosis

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BTNL2 gene variant and sarcoidosis.

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BTNL2 Gene Polymorphism and Sarcoidosis Susceptibility: A Meta-Analysis

BACKGROUND Butyrophilin-like 2 (BTNL2) rs2076530 gene polymorphism has been implicated in susceptibility to sarcoidosis. However, results from previous studies are not consistent. To assess the association of BTNL2 polymorphism and sarcoidosis susceptibility, a meta-analysis was performed. METHODS PubMed, Embase were searched for eligible case-control studies. Data were extracted and pooled o...

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Lack of correlation of BTNL2 polymorphism and cancer risk in sarcoidosis. BTNL2 and cancer risk in sarcoidosis.

BACKGROUND Sarcoidosis is a polygenic immune disorder disease with predominant manifestations in the lung. BTNL2 gene polymorphisms were previously linked to susceptibility to sarcoidosis. Relationships between sarcoidosis and cancers have been suspected for a long time but little evidence has been reported until now, and recent works show a link between butyrophilin family proteins and anti tu...

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Major histocompatibility complex class II and BTNL2 associations in sarcoidosis.

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BTNL2 gene SNPs as a contributing factor to sarcoidosis pathogenesis in a cohort of Greek patients

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology that primarily affects adults between the ages of 20 and 40 years old. It is characterized by the activation of Th1 lymphocytes resulting in the production of inflammatory cytokines and the formation of noncaseating epithelioid cell granulomas in affected tissues. The lungs and lymphatic system are the ones most frequently...

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ژورنال

عنوان ژورنال: Thorax

سال: 2006

ISSN: 0040-6376

DOI: 10.1136/thx.2005.056564